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In other words, its complicatedvery complicated, which has long hindered our understanding of the disease.

Answering the why just may change the course of action in terms of both prevention and treatment.

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For some of the leading experts in Alzheimers research, theyre choosing to focus on the gut.

As withseemingly everything else in health these days,it all comes down to the microbiome.

(Shereceived a grant from WAM in 2020to fund her research.)

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Its important to have ahigh population of certain good bacteria strainsand fungi in the gut.

Heres why: What happens is that as we age, everything starts to break down.

This is normal and natural, and we take a stab at fight it, Dr. Cox says.

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This is called inflamm-aging, akainflammation due to age.

This is problematic for two reasons.

He says that sex hormones and physiology in men and women affect the gut bacteria in the microbiome.

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[This communication] could then modulate what bacteria live and what bacteria die, he says.

Future experiments could involve castrating male mice and studying how that changes their microbiomes in their set-up.

In another experiment, testosterone supplements could be given to female mice to see how that affectstheirmicrobiome.

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Dr. Cox has seen promise with female mice going a different route:reducing carbohydrate intake.

But restricting carbs helped slow that aging process in the female mice, she says.

Were still several years off from that knowledge.

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Its more about eating fewer carbs and enough other beneficial macronutrients like protein, fat, and fiber.

And addressing those differences lies a prevention plan that could be affective for everyone.

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