This makes us wonder: what is an NMN supplement, and what does itexactlydo?

Anecdotally, it works to slow aging, but what does the science say?

We tapped a longevity doctor and registered dietitian to learn more about this popular, yet controversial supplement.

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What is NMN?

NAD+ occurs naturally in our bodys cells, but its productiondecreases as we age1.

(More on this in a bit.)

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longevity expert and chief medical officer atTimeline Nutrition

However, most NMN supplements are produced synthetically.

What are the potential benefits of NMN?

We also dont know how NMN will work for people of different ages and health statuses.

close up of person drinking a green smoothie that may cause their poop to be green

There is not enough research to definitively say NMN supplements can slow or reverse markers of aging.

Heres Exactly How It Can Affect Your Poop

1.

Most reported side effects are mild and can include things likeheadaches and nausea10.

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But, little is known about the long-term side effects of these supplements.

Other active (and inactive) ingredients can cause side effects

Another thing to keep in mind?

McReynolds, Melanie R et al.

cup of matcha green tea sitting on a wooden ledge

longevity expert and chief medical officer atTimeline Nutrition

Age-related NAD+decline.Experimental gerontology, vol.

22 Feb. 2020, doi:10.1016/j.exger.2020.110888

Mehmel, Mario et al.

Nicotinamide Riboside-The Current State of Research and Therapeutic Uses.Nutrientsvol.

LOS ANGELES - FEB 10: Patrick Schwarzenegger at the White Lotus Season 3 Premiere at Paramount Studios on February 10, 2025 in Los Angeles, CA

https://doi.org/10.1186/s12967-024-05614-9

Bai, Long-Bo et al.

Improvement of tissue-specific distribution and biotransformation potential of nicotinamide mononucleotide in combination with ginsenosides or resveratrol.Pharmacology research & perspectivesvol.

10,4 (2022): e00986.

Woman drinking a protein meal replacement shake in the kitchen

doi:10.1002/prp2.986

Yoshino, Mihoko, et al.

Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women.Science, vol.

6547, 11 June 2021, pp.

12241229, https://doi.org/10.1126/science.abe9985.

3, 5 May 2022, https://doi.org/10.3389/fragi.2022.851698.

Shou, J., Chen, PJ.

& Xiao, WH.

Mechanism of increased risk of insulin resistance in aging skeletal muscle.Diabetol Metab Syndr12, 14 (2020).

https://doi.org/10.1186/s12970-021-00442-4

Song, Qin et al.

14,6 (2023): 1416-1435. doi:10.1016/j.advnut.2023.08.008

Yu, Jianjun, et al.

6, 2024, p. 100171, https://doi.org/10.1016/j.crtox.2024.100171.

Zhao, Haotian et al.

Pharmacological Effects of Urolithin A and Its Role in Muscle Health and Performance: Current Knowledge and Prospects.Nutrientsvol.

19 Oct. 2023, doi:10.3390/nu15204441

Yi, Lin et al.

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