EvencelebslikeKendall JennerandHailey Bieberare getting in on the NAD trend.
What is NAD?
NAD, short fornicotinamide adenine dinucleotide, is a naturally occurringbiomoleculefound in all living cells.
Its mainly produced and stored in our cellsmitochondriathe powerhouse of the cell.
Does it work for anti-aging?
However, the research in question is relatively new and limited.
longevity and preventive health expert and co-founder and medical director atAgelessRx
Ultimately, we need more robust human studies to confirm the supposed anti-aging benefits of NAD.
Here is what early research has to say:
1.
Keep in mind: Oral niacinamide has not been widely investigated in humans for skin aging.
FWIW though,moderate exercise15has also been shown to boost NAD+ levels and offset age-related muscle loss.
But keep in mind: These findings are still new and need to be further studied to prove effective.
Here is what the research has to say:
1.
One trial showed thatNMN supplementation improves insulin sensitivity18in post-menopausal people living with obesity.
However, theres not enough evidence to show that these results apply to other groups of people.
Therefore, additional robust research is still needed to confirm these claims.
longevity and preventive health expert and co-founder and medical director atAgelessRx
In the study, NMN supplementation increased oxygen uptake and improved endurance as the exercise intensity increased.
Topical NAD can also cause side effects, including itching, burning, and redness.
Not everyone will benefit from boosting NAD+ levels.
This is why its best to purchase supplements that have beenthird-party testedby reputable companies likeThe United States Pharmacopeial ConventionorNSF.
Its also unclear whether NAD supplements can have a significant positive effect on your overall health.
So, do you need them?
Likely, no (despite what celebs and TikTokers may tell you).
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The Role of NAD+in Metabolic Regulation of Adipose Tissue: Implications for Obesity-Induced Insulin Resistance.Biomedicinesvol.
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Age-Dependent Decline of NAD+-Universal Truth or Confounded Consensus?.Nutrientsvol.
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Yoshino, Mihoko, et al.
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12241229, https://doi.org/10.1126/science.abe9985.
https://doi.org/10.1038/s43587-024-00758-1
Liao, Bagen, et al.
1, 2 Jan. 2021, https://doi.org/10.1186/s12970-021-00442-4.
Freeberg, Kaitlin A et al.
Dietary Supplementation With NAD+-Boosting Compounds in Humans: Current Knowledge and Future Directions.The journals of gerontology.
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78,12 (2023): 2435-2448. doi:10.1093/gerona/glad106
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Evaluation of safety and effectiveness of NAD in different clinical conditions: a systematic review.American journal of physiology.
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