TikTokers say “yes.”

Here’s what the science says.

This is when the search for alternatives happens.

person with brown curly hair in a grey t-shirt and plaid pajama pants sitting on their bed and holding a metal medicine packet of antihistamines for PMDD

But does Pepcid really do the trick?

And is it a safe long-term solution?

Heres what experts had to say about using this particular antihistamine for PMDD.

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a pharmacist, medical writer, and healthcare system expert

First, what is PMDD?

We may feel a bit more emotional, deal with cramps, or crave certain foods before our periods.

But PMDD takes these premenstrual symptoms to a whole different level.

close up of person drinking a green smoothie that may cause their poop to be green

Research has found thathigh histamine levels3in the body are associated with worsened period cramps.

(FYI, your healthcare provider can run certain blood work to determine if you have histamine sensitivity.)

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Medical experts have been curious about the histamine-menstruation connection for decades.

So, do antihistamines actually work for PMDD?

The short answer is…maybe.

cup of matcha green tea sitting on a wooden ledge

a pharmacist, medical writer, and healthcare system expert

But this may also depend on the punch in of antihistamine you reach for.

Lets break down the options.

At most, Pepcid may cause headaches, dizziness, constipation, or diarrhea.

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This is why it’s important to talk to your provider before adding a new medicine to your routine.

They will be your biggest advocate and help you find what works best.

you’re able to also visit988lifeline.orgfor more helpful resources.

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